Scott R L, Albina J E, Caldwell M D
JPEN J Parenter Enteral Nutr. 1982 Nov-Dec;6(6):489-95. doi: 10.1177/0148607182006006489.
Studies were conducted to compare the effects of isocaloric intake of glucose, amino acids, and combinations of these nutrients on nitrogen balance, body composition, and selected metabolic parameters of adult rats. Diets were administered either orally or intravenously at 20% (semi-starvation) of the daily caloric requirement. Although nitrogen balance was improved when all calories were supplied as amino acids when compared to glucose alone, one-half the amino acids could be replaced with glucose without sacrificing nitrogen balance. Animals from the semi-starvation treatment showed similar weight and body composition changes, there was no apparent difference whether the diets were administered orally or intravenously. These results indicate that replacement of at least one-half the calories of an all amino acid hypocaloric diet with glucose does not adversely affect body composition weight change or nitrogen balance, but may reduce blood urea nitrogen, ketosis, and cost of nutritional support.
开展了多项研究，以比较等热量摄入葡萄糖、氨基酸以及这些营养素组合对成年大鼠氮平衡、身体组成和选定代谢参数的影响。日粮按每日热量需求的20%（半饥饿）经口或静脉给予。尽管与仅给予葡萄糖相比，当所有热量都以氨基酸形式提供时氮平衡得到改善，但一半的氨基酸可用葡萄糖替代而不影响氮平衡。半饥饿处理组的动物体重和身体组成变化相似，日粮经口或静脉给予时无明显差异。这些结果表明，用葡萄糖替代全氨基酸低热量日粮中至少一半的热量，不会对身体组成、体重变化或氮平衡产生不利影响，但可能会降低血尿素氮、酮症和营养支持成本。
