Todd W J, Burgdorfer W, Mavros A J
Can J Microbiol. 1982 Dec;28(12):1412-6. doi: 10.1139/m82-212.
A cell line was established from the tunica vaginalis of meadow voles, Microtus pennsylvanicus, which could be persistently infected with the spotted fever group rickettsiae, Rickettsia rickettsii, R. rhipicephali, and R. slovaca. As determined by light and electron microscopy, all cells in the cultures became infected and remained so even after 20 serial passages over a period of months. The rickettsiae-infected vole cell line is an excellent experimental model to study the noncytolytic host-cell interactions required for persistence of spotted fever group rickettsiae in nature.
从草原田鼠（Microtus pennsylvanicus）的鞘膜建立了一种细胞系，该细胞系可被斑点热群立克次体（立氏立克次体、头蜱立克次体和斯洛伐克立克次体）持续感染。通过光学显微镜和电子显微镜观察确定，培养物中的所有细胞均被感染，并且即使在数月内连续传代20次后仍保持感染状态。感染立克次体的田鼠细胞系是研究斑点热群立克次体在自然界中持续存在所需的非细胞溶解性宿主-细胞相互作用的极佳实验模型。
