Fujiwara K
Lab Anim Sci. 1980 Apr;30(2 Pt 2):298-303.
Unhealthy laboratory animals cause not only serious damage in production efficiency but also undesirable changes in animal quality with a high possibility of occurrence of overt diseases during animal experimentation. Most rodent production colonies now use a strict barrier system which protects animals from the introduction of infective agents. However, routine monitoring of the health status in production colonies is required because conventional environments are still common in fields of animal experimentation during which disease control is much more difficult. Disease problems seem to be more serious in testing or research colonies which receive clean, susceptible animals from production colonies. To develop an effective program for health monitoring and control, particularly concerned with infectious diseases, it is indispensable to accumulate more scientific information on the epizootology of rodent diseases with cooperation between both animal production and experimentation.
不健康的实验动物不仅会严重损害生产效率，还会导致动物质量出现不良变化，并且在动物实验期间很有可能出现明显疾病。目前，大多数啮齿动物生产群体都采用严格的屏障系统，以保护动物免受感染因子的侵入。然而，由于在动物实验领域常规环境仍然很常见，而在这种环境中疾病控制要困难得多，因此需要对生产群体的健康状况进行常规监测。在从生产群体接收清洁、易感动物的测试或研究群体中，疾病问题似乎更为严重。为了制定一个有效的健康监测和控制计划，特别是针对传染病的计划，动物生产和实验双方合作积累更多关于啮齿动物疾病流行病学的科学信息是必不可少的。
