Thibert P
Lab Anim Sci. 1980 Apr;30(2 Pt 2):339-51.
Historically, laboratory rodents have been used in preference to other animal species for biomedical research. Study disruptions and invalidations often have occurred due to microbial contaminants inherent to laboratory rodents. Today, many commercial suppliers and research institutions are controlling a variety of infectious diseases among laboratory rodents by careful design of animal facilities, by adaptation of managerial techniques employing precise operational policies coupled with careful supervision and attention to detail and the use of various diagnostic programs. The continued evolution of epidemiological practices, environment control systems, sophistication of barrier-sustained operations, preventative medicine and sanitation techniques, complemented by an improvement in veterinary diagnostic programs for disease surveillance further minimize microbial contamination of laboratory rodents. Such measures contribute to the fulfillment of various legislative requirements concerned with the quality of animals for biomedical research.
从历史上看，在生物医学研究中，实验用啮齿动物比其他动物物种更受青睐。由于实验用啮齿动物固有的微生物污染物，研究经常出现中断和无效的情况。如今，许多商业供应商和研究机构通过精心设计动物设施、采用精确操作政策并辅以仔细监督和注重细节的管理技术以及运用各种诊断程序，来控制实验用啮齿动物中的多种传染病。流行病学实践、环境控制系统、屏障维持操作的复杂性、预防医学和卫生技术的不断发展，再加上用于疾病监测的兽医诊断程序的改进，进一步减少了实验用啮齿动物的微生物污染。这些措施有助于满足与生物医学研究用动物质量相关的各种立法要求。
