Platka-Bird L, Bennink M R
J Nutr. 1978 Sep;108(9):1422-30. doi: 10.1093/jn/108.9.1422.
Pregnant rats were pair-fed isoenergetic diets with varying fat content and varying fatty acid compositions to determine if manipulation of the maternal diet would affect fetal lipid metabolism. A mixture of tallow and lard replaced cornstarch on an equal-energy basis so that fat supplied 5 to 65% of the metabolizable energy. Fat content of the maternal diet did not affect fetal weight or fetal body composition. No differences in fetal liver fatty acid synthetase (FAS), glucose-6-phosphate dehydrogenase (G6PD) activities or rate of in vivo fatty acid synthesis were noted. In vivo fatty acid synthesis was greater in fetal liver than maternal liver. Dietary manipulation did not affect in vivo fatty acid synthesis in either fetal or maternal liver. Maternal liver FAS and G6PD activities were generally greater than fetal liver FAS and G6PD activities. These enzyme activities were decreased in maternal livers when the high-fat diet was fed. A sudden decrease in food consumption 24 hours before killing may explain the apparent inconsistencies in enzyme activities and fatty acid synthesis rates. The results of this study indicate that the level of fat in the maternal diet has no effect on the amount of lipid accumulated in fetal tissues or fetal lipogenesis.
将怀孕大鼠成对饲养，给予能量相等但脂肪含量和脂肪酸组成不同的饮食，以确定母体饮食的改变是否会影响胎儿的脂质代谢。用牛脂和猪油的混合物等量替代玉米淀粉，使脂肪提供5%至65%的可代谢能量。母体饮食的脂肪含量不影响胎儿体重或胎儿身体组成。未观察到胎儿肝脏脂肪酸合成酶（FAS）、葡萄糖-6-磷酸脱氢酶（G6PD）活性或体内脂肪酸合成速率的差异。胎儿肝脏中的体内脂肪酸合成高于母体肝脏。饮食调整对胎儿或母体肝脏中的体内脂肪酸合成均无影响。母体肝脏FAS和G6PD活性通常高于胎儿肝脏FAS和G6PD活性。喂食高脂饮食时，母体肝脏中的这些酶活性降低。处死前24小时食物摄入量的突然减少可能解释了酶活性和脂肪酸合成速率明显不一致的情况。本研究结果表明，母体饮食中的脂肪水平对胎儿组织中积累的脂质数量或胎儿脂肪生成没有影响。
