去甲肾上腺素能背侧升束的单侧阻断与海马θ节律的隔区诱发

Unilateral blockade of the dorsal ascending noradrenergic bundle and septal elicitation of hippocampal theta rhythm.

作者信息

McNaughton N, Kelly P H, Gray J A

出版信息

Neurosci Lett. 1980 May 15;18(1):67-72. doi: 10.1016/0304-3940(80)90214-1.

PMID:6820484

Abstract

Unilateral blockade of the dorsal ascending noradrenergic bundle was produced by injections of procaine or of 6-hydroxydopamine. The threshold current of septal stimulation required to drive the hippocampal theta rhythm was then investigated at frequencies between 5.9 and 10.0 Hz. With both types of blockade the threshold-frequency function showed a normal 7.7 Hz minimum ipsilaterally and an abolition of the minimum contralaterally. Ventral noradrenergic bundle lesions had no effect. Septal elicitation of hippocampal theta rhythm may, therefore, be dependent on a noradrenergic mechanism controlling aspects of the theta rhythm, e.g. interhemispheric balance, which would not be obvious in ordinary spontaneous records.

摘要

通过注射普鲁卡因或6-羟基多巴胺对背侧上行去甲肾上腺素能束进行单侧阻断。然后在5.9至10.0Hz的频率范围内研究驱动海马θ节律所需的隔区刺激阈值电流。在两种类型的阻断情况下，阈值-频率函数在同侧显示出正常的7.7Hz最小值，而在对侧最小值消失。腹侧去甲肾上腺素能束损伤没有影响。因此，隔区引发海马θ节律可能依赖于一种去甲肾上腺素能机制，该机制控制着θ节律的某些方面，例如半球间平衡，这在普通的自发记录中并不明显。