Hirn S, Pietschmann H
Wien Klin Wochenschr. 1982 Dec 24;94(24):662-5.
At a geriatric department 61 insulin-dependent diabetics have been treated with des-phe-insulin (DPI) for periods of up to 6 years since 1976. The use of either pure DPI, amorphous DPI or DPI mixed with varying amounts of crystalline non-modified insulin of the same species allowed flexible longterm therapy, as well as management of metabolic emergencies. Comparison of the doses needed before and after change to and from other insulin preparations showed no difference in efficacy. No side effects of such severity as to necessitate interruption of therapy were observed.
自1976年以来，在一家老年病科，61名胰岛素依赖型糖尿病患者接受了去苯丙氨酸胰岛素（DPI）治疗，治疗时间长达6年。使用纯DPI、无定形DPI或与不同量相同物种的结晶非修饰胰岛素混合的DPI，既可以进行灵活的长期治疗，也可以处理代谢急症。与换用其他胰岛素制剂前后所需剂量相比，疗效无差异。未观察到严重到需要中断治疗的副作用。
