Sachse G, Federlin K
Med Klin. 1981 May 22;76(11):319-23.
Des-phe-insulins are modified insulins in which phenylalanin is eliminated from the b-chain of the normal insulin. Preparations containing des-phe-insulin and cristalline insulin have a good stability and one can produce insulins with different profiles. 50 diabetics were treated with different des-phe-insulin containing preparations. The carbohydrate metabolism was well controlled during the application of the new preparations. There were no side effects nor skin allergies. Des-phe-insulin containing insulins present a new interesting aspect in the treatment of insulin dependent diabetes mellitus.
去苯丙氨酸胰岛素是一种经过修饰的胰岛素，其中苯丙氨酸从正常胰岛素的β链中被去除。含有去苯丙氨酸胰岛素和结晶胰岛素的制剂具有良好的稳定性，并且可以生产出具有不同特性的胰岛素。50名糖尿病患者接受了不同的含去苯丙氨酸胰岛素制剂的治疗。在使用新制剂期间，碳水化合物代谢得到了良好的控制。没有出现副作用和皮肤过敏现象。含去苯丙氨酸胰岛素的胰岛素在胰岛素依赖型糖尿病的治疗中展现出了一个新的有趣方面。
