Perkins E S
Trans Ophthalmol Soc U K (1962). 1981 Sep;101 (Pt 3)(3):304-7.
The discovery of associations between HLA antigens and particular diseases has provided an explanation for some racial differences in the incidence of uveitis. Acute anterior uveitis is strongly associated with HLA B27 and this hereditary influence has been substantiated by evidence of familial cases. HLA B5 occurs more frequently in Japanese patients with Behçet's disease and HLA BW22J and HLA DWa are associated with the Vogt-Koyanagi-Harada disease. HLA B7 and HLA DRW2 occur more frequently in patients with presumed ocular histoplasmosis. Some possible explanations for these associations are discussed. Syphilis, cytomegalic inclusion disease, and toxoplasmosis can all produce a congenital form of uveitis.
人类白细胞抗原（HLA）抗原与特定疾病之间关联的发现，为葡萄膜炎发病率的一些种族差异提供了解释。急性前葡萄膜炎与HLA B27密切相关，家族性病例的证据证实了这种遗传影响。HLA B5在日本贝赫切特病患者中出现的频率更高，而HLA BW22J和HLA DWa与小柳原田病有关。HLA B7和HLA DRW2在疑似眼组织胞浆菌病患者中出现的频率更高。本文讨论了这些关联的一些可能解释。梅毒、巨细胞包涵体病和弓形虫病都可导致先天性葡萄膜炎。
