Matsumoto K, Asakawa H, Otawa H, Yamada S
Gan To Kagaku Ryoho. 1982 Feb;9(2):301-5.
A total of 58 cases with inoperable advanced gastric carcinomas were treated by radiotherapy combined with tegafur, and the result was analyzed mainly from the aspects of life expectancies and some prognostic factors. Median survival time of all cases was 8.9 months. Actuarial survival rates at one, two, three, four and five years were 45%, 22%, 14%, 14% and 11% respectively. Cancer type, histologic type, tumor size and radiation effect on the primary lesion were chosen as the prognostic factors, and examined using median survival time as a parameter. Borrmann IV type cancer showed an unequivocally poor prognosis, whereas no significant prognostic differences were seen among other types. Poorly differentiated adenocarcinoma gave a poor prognosis. Radiation effect on the primary lesion seemed to have a positive correlation with prognosis, while life expectancies became shorter with the increase of tumor size. It seems, from the present study, that this combination therapy contributes a great deal to life prolongation of patients with inoperable advanced gastric carcinomas.
对58例无法手术的晚期胃癌患者采用放疗联合替加氟进行治疗，并主要从生存期及一些预后因素方面对结果进行分析。所有病例的中位生存时间为8.9个月。1年、2年、3年、4年和5年的精算生存率分别为45%、22%、14%、14%和11%。将癌症类型、组织学类型、肿瘤大小以及原发灶的放疗效果作为预后因素，以中位生存时间作为参数进行检验。Borrmann Ⅳ型癌症预后明显较差，而其他类型之间未见显著的预后差异。低分化腺癌预后较差。原发灶的放疗效果似乎与预后呈正相关，而生存期随肿瘤大小的增加而缩短。从本研究来看，这种联合治疗对无法手术的晚期胃癌患者的生存期延长有很大贡献。
