Arima S, Futami K, Kinashi M, Shigeta M, Jyozaki H, Shimura H
Gan To Kagaku Ryoho. 1983 Aug;10(8):1788-95.
Advanced gastric cancer cases (42 cases) undergone gastrectomy were studied on the correlation between tissue uptakes and prognosis. The patients were administrated Tegafur preoperatively and tissue samples were obtained intraoperatively, 5-FU levels in tumor and lymph node were measured by GCMF. The patients, being measured 5-FU uptake by tissue and received Tegafur over 60 g as postoperative adjuvant chemotherapy, were divided into two groups; namely, one with 5-FU up take by tumor tissue and lymph node was higher than 0.05 mcg/g and the other with lower than 0.05 mcg/g. Both groups showed no significant difference in background factors. Each survival rate was calculated by Kaplan-Meier method and examined by generalized Wilcoxon method. As the result, there was no significant correlation in the 5-FU uptake by tumor and prognosis, but prolongation of survival rate in the group of 5-FU uptake by lymph node over 0.05 mcg/g was suggested.
对42例接受胃切除术的进展期胃癌病例进行了组织摄取与预后相关性的研究。患者术前给予替加氟，术中获取组织样本，采用气相色谱-质谱联用仪测定肿瘤和淋巴结中的5-氟尿嘧啶水平。对通过组织测定5-氟尿嘧啶摄取量且术后辅助化疗接受替加氟超过60 g的患者分为两组；即肿瘤组织和淋巴结5-氟尿嘧啶摄取量高于0.05 mcg/g的一组和低于0.05 mcg/g的另一组。两组在背景因素方面无显著差异。采用Kaplan-Meier法计算各生存率，并通过广义Wilcoxon法进行检验。结果显示，肿瘤5-氟尿嘧啶摄取量与预后无显著相关性，但提示淋巴结5-氟尿嘧啶摄取量超过0.05 mcg/g的组生存率延长。
