Lloyd-Still J D, Demers L M
J Pediatr Surg. 1978 Aug;13(4):417-8. doi: 10.1016/s0022-3468(78)80467-9.
An infant with Hirschsprung's enterocolitis developed a fulminant secretory diarrhea unresponsive to all conventional therapy until cholestyramine was administered. A 12-fold decrease in prostaglandin E (PGE) levels in the colostomy fluid was documented in response to cholestyramine therapy. It is postulated that increased PGE activity, enterotoxin, and bile acid malabsorption may be involved in the enterocolitis of Hirschsprung's disease.
一名患有先天性巨结肠病合并小肠结肠炎的婴儿出现了暴发性分泌性腹泻，对所有常规治疗均无反应，直到给予消胆胺治疗。记录显示，给予消胆胺治疗后，结肠造口液中前列腺素E（PGE）水平下降了12倍。据推测，PGE活性增加、肠毒素和胆汁酸吸收不良可能与先天性巨结肠病的小肠结肠炎有关。
