亚硝酸丁酯的急性经口毒性
Acute oral toxicity of butyl nitrite.
作者信息
Wood R W, Cox C
出版信息
J Appl Toxicol. 1981 Feb;1(1):30-1. doi: 10.1002/jat.2550010108.
PMID:6821079
Abstract
Butyl nitrite is present in consumer products subject to abuse by inhalation. When inhaled, intense peripheral vasodilation and tachycardia ensue, described by users as a 'rush'. When ingested, toxic sequelae include methemoglobinemia and hypokinetic anoxia. The median lethal oral dose to rats of this compound is, with 95% confidence, 83 +/- 3.5 mg kg-1.
摘要
亚硝酸丁酯存在于可能被吸入滥用的消费品中。吸入后，会出现强烈的外周血管舒张和心动过速，使用者将其描述为“一阵快感”。摄入后，毒性后果包括高铁血红蛋白血症和低动力性缺氧。该化合物对大鼠的经口半数致死剂量，95%置信区间为83±3.5毫克/千克。
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