Cohn D V, Zangerle R, Fischer-Colbrie R, Chu L L, Elting J J, Hamilton J W, Winkler H
Proc Natl Acad Sci U S A. 1982 Oct;79(19):6056-9. doi: 10.1073/pnas.79.19.6056.
We have compared the amino acid and carbohydrate compositions, partial amino acid sequences, immunological crossreactivity, and physical properties of secretory protein I of the parathyroid gland and chromogranin A of adrenal gland. This comparison indicates that these proteins are similar molecules. Because secretory protein I is present in secretory granules containing parathormone and is cosecreted with the hormone, and because chromogranin A is contained within chromaffin granules and, likewise, is secreted with the catecholamines, the present observations raise the possibility that this class of protein plays a general role in hormone secretion or storage mechanisms.
我们比较了甲状旁腺分泌蛋白I和肾上腺嗜铬粒蛋白A的氨基酸组成、碳水化合物组成、部分氨基酸序列、免疫交叉反应性及物理性质。这种比较表明这些蛋白质是相似的分子。由于分泌蛋白I存在于含有甲状旁腺激素的分泌颗粒中，并与该激素共同分泌，且由于嗜铬粒蛋白A存在于嗜铬颗粒中，同样也与儿茶酚胺一起分泌，目前的观察结果提出了这类蛋白质在激素分泌或储存机制中发挥普遍作用的可能性。
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