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Evolution of tubulin heterogeneity during mouse brain development.

作者信息

Denoulet P, Edde B, Jeantet C, Gros F

出版信息

Biochimie. 1982 Mar;64(3):165-72. doi: 10.1016/s0300-9084(82)80466-5.

DOI:10.1016/s0300-9084(82)80466-5
PMID:6821154
Abstract

In this report, we have characterized tubulin subunit heterogeneity and its evolution during mouse brain development, from embryonic to adult stages. A modification of the two-dimensional protein analysis was used to specify these events. The number of isotubulins increases from 6 (4 alpha and 2 beta), in the embryonic brain, to 11 (6 alpha and 5 beta), in the adult. The changes occurring in tubulin heterogeneity are developmentally controlled but it seems that alpha and beta isotubulins are independently regulated: changes in alpha tubulin occur only just before birth whereas the major evolution is concerned with the appearance and accumulation of acidic beta isotubulins throughout development.

摘要

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