Drummond G B, Zhong N S
Br J Anaesth. 1983 Jan;55(1):3-13. doi: 10.1093/bja/55.1.3.
Arterial oxygenation was measured in patients being ventilated artificially for respiratory failure, initially at the FIO2 that had been selected clinically to achieve PaO2 at least normal, and then at each of two or three progressively increased FIO2 values up to about 0.9. Impairment of oxygen transfer was assessed by the difference between calculated pulmonary end-capillary and arterial oxygen content (Cc'O2-CaO2). Reasons are presented to support the assumption that this value indicates the degree of venous admixture. In patients with severely impaired gas exchange ((Cc'O2-CaO2) greater than 1 ml dl-1), the first increase in inspired oxygen decreased the impairment: less severely impaired lungs showed no change. The observations are consistent with the ventilation/perfusion mismatch hypothesis and do not show that increased oxygen impairs pulmonary oxygenating efficiency.
对因呼吸衰竭接受人工通气的患者测量动脉血氧合情况，最初在临床选择的能使动脉血氧分压（PaO2）至少达到正常水平的吸入氧分数（FIO2）下进行测量，然后在两到三个逐渐增加的FIO2值下分别进行测量，直至约0.9。通过计算的肺毛细血管末端与动脉血氧含量之差（Cc'O2-CaO2）来评估氧转运受损情况。文中给出了支持该值可指示静脉血掺杂程度这一假设的理由。在气体交换严重受损（Cc'O2-CaO2大于1 ml dl-1）的患者中，吸入氧的首次增加减轻了损伤；受损程度较轻的肺部则无变化。这些观察结果与通气/灌注不匹配假说相符，并未表明增加吸氧会损害肺的氧合效率。
