Bistoletti P, Lagercrantz H, Lunell N O
Br J Obstet Gynaecol. 1983 Jan;90(1):11-5. doi: 10.1111/j.1471-0528.1983.tb06738.x.
Fetal heart-rate (FHR) variability was studied in 50 term fetuses during the first stage of labour. The variability was computed as an arbitrary index during a 20-min period preceding a fetal scalp blood sample which was used for the measurement of pH, adrenaline and noradrenaline. None of the fetuses was found to have a scalp blood pH less than 7.2. The short-term variability index was significantly correlated with the noradrenaline concentration in fetal blood, but the adrenaline levels which were generally very low showed no correlation with the variability values. There was no correlation between variability index and cervical dilatation or blood pH. We have shown previously high plasma catecholamine concentrations in the asphyxiated fetus with a decreased pH. In this study where fetal pH was normal a correlation between FHR variability and fetal scalp plasma noradrenaline levels was found. Thus an increased FHR variability might be an early sign of fetal distress when fetal pH is still normal.
在50例足月胎儿第一产程中对胎儿心率（FHR）变异性进行了研究。在采集用于测量pH值、肾上腺素和去甲肾上腺素的胎儿头皮血样本前20分钟内，将变异性计算为一个任意指数。未发现有胎儿头皮血pH值低于7.2。短期变异性指数与胎儿血液中去甲肾上腺素浓度显著相关，但通常很低的肾上腺素水平与变异性值无相关性。变异性指数与宫颈扩张或血液pH值之间无相关性。我们之前已经表明，pH值降低的窒息胎儿血浆儿茶酚胺浓度较高。在本研究中，胎儿pH值正常，发现FHR变异性与胎儿头皮血浆去甲肾上腺素水平之间存在相关性。因此，当胎儿pH值仍正常时，FHR变异性增加可能是胎儿窘迫的早期迹象。
