Amdur M O
J Toxicol Environ Health. 1978 Jul;4(4):619-30. doi: 10.1080/15287397809529684.
Respiratory function measurements in guinea pigs were used to evaluate the irritant response to 1-h exposures to iodine vapor and the effect of 10 mg/m(3) submicrometer sodium chloride aerosol on this response. Iodine alone at 0.5 ppm produced no detectable response. Concentrations of 3-4 ppm increased resistance and decreased frequency and minute volume. The response appeared to be upper respiratory. At 7 ppm there was also a decrease in compliance, suggesting pulmonary effects. The response was potentiated by the sodium chloride aerosol. Increased resistance and decreased compliance and frequency were observed at 0.4 ppm. The changes at concentrations of 1-2 ppm were greater when the aerosol was present and included a decrease in compliance. The comparative effects of the sodium chloride aerosol on iodine, sulfur dioxide, and formaldehyde are discussed.
通过对豚鼠进行呼吸功能测量，来评估其对1小时碘蒸气暴露的刺激反应，以及10毫克/立方米亚微米级氯化钠气溶胶对该反应的影响。单独的0.5 ppm碘未产生可检测到的反应。3 - 4 ppm的浓度会增加阻力、降低频率和分钟通气量。该反应似乎主要在上呼吸道。7 ppm时顺应性也降低，提示有肺部影响。氯化钠气溶胶会增强该反应。在0.4 ppm时观察到阻力增加、顺应性和频率降低。当存在气溶胶时，1 - 2 ppm浓度下的变化更大，包括顺应性降低。文中还讨论了氯化钠气溶胶对碘、二氧化硫和甲醛的比较影响。
