Mizukami S, Nishizuka M, Arai Y
Exp Neurol. 1983 Feb;79(2):569-75. doi: 10.1016/0014-4886(83)90235-2.
Nuclear volume of the medial and lateral nuclei of the amygdala was investigated in male and female rats. The volume of the medial nucleus in the adult male rat was significantly greater than that of the female rat. Treatment of female rats with estrogen for the first 30 days of postnatal life increased the nuclear size, and the volume became comparable to that of the males. Although there was no significant difference in volume of this nucleus between male and female rats from days 1 (day of birth) to 11, the difference became evident at day 21, and thereafter it persisted. In contrast, the nuclear volume of the lateral nucleus was not different between the two sexes. Estrogen treatment did not influence the volume of the lateral nucleus in the female animals. These data indicate that the nuclear volume is sexually different in the medial nucleus of the amygdala, and its differentiation occurs during the early postnatal period under the influence of the organizational action of sex steroids.
研究了雄性和雌性大鼠杏仁核内侧核与外侧核的核体积。成年雄性大鼠内侧核的体积显著大于雌性大鼠。在出生后的前30天用雌激素处理雌性大鼠可增加核大小，其体积变得与雄性大鼠相当。虽然从出生第1天到第11天，雄性和雌性大鼠该核的体积没有显著差异，但在第21天差异变得明显，此后一直持续。相比之下，外侧核的核体积在两性之间没有差异。雌激素处理对雌性动物外侧核的体积没有影响。这些数据表明，杏仁核内侧核的核体积存在性别差异，其分化在出生后早期在性类固醇的组织作用影响下发生。
