神经免疫学与神经表观遗传学在大脑性别差异形成中的作用
Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain.
作者信息
McCarthy Margaret M, Nugent Bridget M, Lenz Kathryn M
机构信息
Department of Pharmacology and Program in Neuroscience, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, Maryland 21201, USA.
University of Pennsylvania, Department of Biomedical Sciences, University of Pennsylvania, 380 S. University Ave, Philadelphia, Pennsylvania 19104, USA.
出版信息
Nat Rev Neurosci. 2017 Aug;18(8):471-484. doi: 10.1038/nrn.2017.61. Epub 2017 Jun 22.
Abstract
The study of sex differences in the brain is a topic of neuroscientific study that has broad reaching implications for culture, society and biomedical science. Recent research in rodent models has led to dramatic shifts in our views of the mechanisms underlying the sexual differentiation of the brain. These include the surprising discoveries of a role for immune cells and inflammatory mediators in brain masculinization and a role for epigenetic suppression in brain feminization. How and to what degree these findings will translate to human brain development will be questions of central importance in future research in this field.
摘要
大脑性别差异的研究是神经科学研究的一个课题，对文化、社会和生物医学科学有着广泛的影响。最近在啮齿动物模型中的研究使我们对大脑性别分化潜在机制的看法发生了巨大转变。这些发现包括免疫细胞和炎症介质在大脑男性化过程中发挥作用的惊人发现，以及表观遗传抑制在大脑女性化过程中发挥作用的发现。这些发现如何以及在多大程度上适用于人类大脑发育，将是该领域未来研究的核心重要问题。
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