粗球孢子菌疫苗：一种碱溶性、水溶性细胞壁抗原的潜力。
Coccidioides immitis vaccine: potential of an alkali-soluble, water-soluble cell wall antigen.
作者信息
Lecara G, Cox R A, Simpson R B
出版信息
Infect Immun. 1983 Jan;39(1):473-5. doi: 10.1128/iai.39.1.473-475.1983.
Abstract
C-ASWS-M, the alkali-soluble, water-soluble cell wall antigen of Coccidioides immitis mycelia, was evaluated for its vaccine potential in mice. Vaccination with 0.5-, 1.5-, or 3-mg doses of C-ASWS-M in complete Freund adjuvant provided a significant level of protection against intraperitoneal challenge with 1,500 arthroconidia (P < 0.0001 with each dose). Vaccination with 1 mg of C-ASWS-M protected mice against intranasal challenge with 50 (P < 0.05) and 500 (P < 0.01) arthroconidia, but not against intranasal challenge with 1,500 arthroconidia (P > 0.05).
摘要
球孢子菌菌丝体的碱溶性、水溶性细胞壁抗原C-ASWS-M在小鼠体内的疫苗潜力得到了评估。在完全弗氏佐剂中用0.5毫克、1.5毫克或3毫克剂量的C-ASWS-M进行疫苗接种，可提供显著水平的保护，抵御1500个关节孢子的腹腔攻击（每剂P<0.0001）。用1毫克C-ASWS-M进行疫苗接种可保护小鼠抵御50个（P<0.05）和500个（P<0.01）关节孢子的鼻内攻击，但不能抵御1500个关节孢子的鼻内攻击（P>0.05）。
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