通过用重组抗原2/PRA接种疫苗保护小鼠免受鼻内感染球孢子菌。
Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA.
作者信息
Shubitz Lisa, Peng Tao, Perrill Robert, Simons Julie, Orsborn Kris, Galgiani John N
机构信息
Valley Fever Center for Excellence, Medicine and Subspecialties Program, Research Program, Southern Arizona Veterans Affairs Health Care System, Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona 85723, USA.
出版信息
Infect Immun. 2002 Jun;70(6):3287-9. doi: 10.1128/IAI.70.6.3287-3289.2002.
Abstract
Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.
摘要
用重组抗原2/球孢子菌病抗原（rAg2/PRA）进行皮下接种可保护BALB/c小鼠免受鼻内感染粗球孢子菌。皮下接种的C57BL/6小鼠和鼻内接种的BALB/c小鼠能抵御更多数量的感染性孢子。体重减轻与致死率相关，但组织学表现并非如此。这些研究支持使用rAg2/PRA疫苗接种来预防球孢子菌病。
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本文引用的文献
1
Immunization of mice with viable Cocidioides immitis.用活的粗球孢子菌对小鼠进行免疫接种。
J Immunol. 1961 Jan;86:28-34.
2
Mucosal vaccination against influenza: protection of pigs immunized with inactivated virus and ether-split vaccine.流感的黏膜疫苗接种：用灭活病毒和乙醚裂解疫苗免疫猪的保护作用。
Jpn J Vet Res. 2001 Feb;48(4):197-203.
3
Coccidioides immitis isolated from armadillos (Dasypus novemcinctus) in the state of Piauí, northeast Brazil.从巴西东北部皮奥伊州犰狳（九带犰狳）中分离出的粗球孢子菌。
Mycopathologia. 2001;149(2):57-61. doi: 10.1023/a:1007273019647.
4
Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995-1996.重度肺部及播散性球孢子菌病的危险因素：加利福尼亚州克恩县，1995 - 1996年
Clin Infect Dis. 2001 Mar 1;32(5):708-15. doi: 10.1086/319203. Epub 2001 Feb 28.
5
Constrictive pericarditis secondary to Coccidioides immitis infection in a dog.犬球孢子菌感染继发缩窄性心包炎
J Am Vet Med Assoc. 2001 Feb 15;218(4):537-40, 526. doi: 10.2460/javma.2001.218.537.
6
Feline systemic fungal infections.猫全身性真菌感染。
Vet Clin North Am Small Anim Pract. 2000 Sep;30(5):1029-50. doi: 10.1016/s0195-5616(00)05005-1.
7
Flow cytometric assessment of human peripheral blood mononuclear cells in response to a coccidioidal antigen.流式细胞术评估人类外周血单个核细胞对球孢子菌抗原的反应。
Med Mycol. 2000 Apr;38(2):127-32. doi: 10.1080/mmy.38.2.127.132.
8
Coccidioidomycosis in human immunodeficiency virus-infected persons in Arizona, 1994-1997: incidence, risk factors, and prevention.1994 - 1997年亚利桑那州人类免疫缺陷病毒感染者的球孢子菌病：发病率、危险因素及预防
J Infect Dis. 2000 Apr;181(4):1428-34. doi: 10.1086/315401. Epub 2000 Apr 7.
9
Induction of antigen-specific T cell responses in human volunteers after intranasal immunization with a whole-cell pertussis vaccine.
Vaccine. 2000 May 8;18(22):2323-30. doi: 10.1016/s0264-410x(00)00024-4.
10
Genetic evidence for the role of the Lv locus in early susceptibility but not IL-10 synthesis in experimental coccidioidomycosis in C57BL mice.
J Infect Dis. 2000 Feb;181(2):681-5. doi: 10.1086/315256.
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