Spears J R, Serur J, Shropshire D, Paulin S
J Clin Invest. 1983 Feb;71(2):395-9. doi: 10.1172/jci110782.
Fluorescence of hematoporphyrin derivative (HPD) has been used clinically to localize malignant neoplasms because of its selective accumulation in these tissues. We tested the hypothesis that HPD may also be selectively concentrated within atheromatous plaques. 48 h after HPD injection in a variety of species, selective fluorescence of atheromatous plaques of the aorta was seen in each animal (rabbits and Patas monkey) exhibiting such lesions. No fluorescence could be demonstrated in aortic segments free of atheromatous involvement. Since the efficacy of photodynamic destruction of malignant tumors with HPD has been demonstrated in clinical studies, the observations of the present study may have therapeutic implications in atheromatosis.
血卟啉衍生物（HPD）的荧光因其在恶性肿瘤组织中的选择性蓄积而被临床用于定位恶性肿瘤。我们检验了HPD也可能选择性地浓集于动脉粥样硬化斑块内这一假说。在多种动物注射HPD 48小时后，在每只出现此类病变的动物（兔和派塔斯猴）中均可见主动脉粥样硬化斑块的选择性荧光。在无动脉粥样硬化累及的主动脉节段未显示荧光。由于临床研究已证实HPD对恶性肿瘤的光动力破坏疗效，本研究的观察结果可能对动脉粥样硬化病具有治疗意义。
