Frank A L, Taber L H, Wells J M
J Infect Dis. 1983 Jan;147(1):120-4. doi: 10.1093/infdis/147.1.120.
Participants in the Houston Family Study were observed during a period of two mixed outbreaks due to two subtypes of influenza A virus: H3N2 and H1N1 (1977-1981). Virus specimens, serum samples, and clinical records were obtained to identify and characterize infections. In 1977-1978, 40% of 238 persons in 59 families were infected by influenza A virus (H3N2), 11% by influenza A virus (H1N1), and 4% by both. In 1980-1981, for 319 persons in 79 families, the corresponding rates were 27%, 20%, and 5%. Interference between subtypes was not detected. Both subtypes were isolated from six children (range of intervals between isolations, six to 55 days), and five of the six were ill with both infections. Nineteen persons had two infections with one or both detected serologically; illnesses were associated with 77% of isolates and up to 56% of seroconversions in these persons. Infection of the same individual with two subtypes in the same season is a newly observed phenomenon that may affect the future epidemiology of influenza A virus as well as preventive measures.
在休斯顿家庭研究中，研究对象在1977年至1981年期间经历了由两种甲型流感病毒亚型（H3N2和H1N1）引起的两次混合疫情。采集了病毒样本、血清样本和临床记录，以识别和描述感染情况。在1977年至1978年期间，59个家庭的238人中，40%感染了甲型流感病毒（H3N2），11%感染了甲型流感病毒（H1N1），4%同时感染了这两种病毒。在1980年至1981年期间，79个家庭的319人中，相应的感染率分别为27%、20%和5%。未检测到亚型之间的干扰。两种亚型均从6名儿童中分离出来（两次分离之间的间隔时间为6至55天），6名儿童中有5名同时感染了这两种病毒。19人有两次感染，其中一次或两次通过血清学检测到；这些人的疾病与77%的分离株以及高达56%的血清转化有关。同一个人在同一季节感染两种亚型是一种新观察到的现象，可能会影响甲型流感病毒未来的流行病学以及预防措施。
