Graham G D, Lundy M M, Frederick R J, Berger D E, O'Brien A W, Brown T J
J Nucl Med. 1983 Feb;24(2):110-3.
The right tibias of sixty-six rabbits were injected with a suspension of Staphylococcus aureus and sodium morrhuate. After four weeks, 43 rabbits developed osteomyelitis and were started on a course of antibiotics. During treatment a gallium-67 scintigram was obtained every two weeks, for up to 10 weeks. During the treatment weeks, 25 rabbits developed negative gallium-67 scintigrams and were killed. All 25 had negative bacteriologic cultures of the right tibia. At the end of 10 wk after start of treatment, the 18 rabbits with persistently positive scintigrams were killed. Eleven of these had positive bacteriologic cultures of the tibia, and seven were negative. The findings suggest that sequential gallium-67 scintigrams may be useful in predicting the cure of osteomyelitis during treatment.
给66只兔子的右胫骨注射金黄色葡萄球菌和鱼肝油酸钠混悬液。四周后，43只兔子发生骨髓炎并开始使用抗生素疗程。治疗期间，每两周进行一次镓67闪烁扫描，最长持续10周。在治疗周期间，25只兔子镓67闪烁扫描结果为阴性并被处死。所有25只兔子右胫骨细菌培养均为阴性。治疗开始10周结束时，18只闪烁扫描结果持续为阳性的兔子被处死。其中11只兔子胫骨细菌培养为阳性，7只为阴性。这些发现表明，连续的镓67闪烁扫描可能有助于预测治疗期间骨髓炎的治愈情况。
