Ghosh T K, Cera P J
Obstet Gynecol. 1983 Jan;61(1):126-30.
The transition from benign adenosis to clear cell carcinoma of the vagina has not been established beyond doubt. The history of a patient regularly followed in a diethystilbestrol (DES) clinic shows initial benign adenosis with normal cytology and subsequent development of abnormal cytology and clear cell adenocarcinoma. The authors suspect transition from benign epithelium to malignancy; however, detailed serial histologic study failed to show clear transition. Frequent and thorough examination of DES patients is needed if malignant change is to be diagnosed early.
从良性腺病转变为阴道透明细胞癌尚未得到确凿证实。一名在己烯雌酚（DES）诊所定期随访的患者，其病史显示最初为良性腺病且细胞学正常，随后出现细胞学异常及透明细胞腺癌。作者怀疑是从良性上皮转变为恶性；然而，详细的系列组织学研究未能显示出明确的转变。如果要早期诊断恶性变化，就需要对DES患者进行频繁且彻底的检查。
