Veridiano N P, Tancer M L, Delke I, Gal D, Giannattasio C
Obstet Gynecol. 1981 Mar;57(3):395-8.
Clear cell adenocarcinoma of the vagina occurred in a diethylstilbestrol (DES)-exposed patient in the fourth year of continuous observation for adenosis. Diagnosis was suspected by digital and colposcopic examination and confirmed by target biopsy. Cytology was negative. The development of malignancy in a patient who has been known to have adenosis has been previously described but is very rare. The necessity for careful regular follow-up using cytology, digital palpation, and colposcopy at 6-month intervals is emphasized.
在对一名患子宫腺病的患者进行连续观察的第四年，该患者发生了阴道透明细胞腺癌。通过指诊和阴道镜检查怀疑诊断，并经靶向活检得以确诊。细胞学检查结果为阴性。此前已有关于已知患有子宫腺病的患者发生恶性肿瘤的报道，但极为罕见。强调有必要每6个月进行一次细胞学检查、指诊和阴道镜检查，进行仔细的定期随访。
