Patterson D J, Dew E W, Gyorkey F, Graham D Y
South Med J. 1983 Feb;76(2):239-41. doi: 10.1097/00007611-198302000-00023.
We report a case of severe liver injury occurring on two occasions in a patient ingesting large doses of nicotinic acid. The liver architecture was markedly distorted, with both massive and submassive lobular collapse and marked cholestasis. Complete resolution of biochemical and histologic abnormalities occurred after withdrawal of these drugs.
我们报告了一例在摄入大剂量烟酸的患者身上两次发生严重肝损伤的病例。肝脏结构明显扭曲,出现大片和亚大片小叶塌陷以及明显的胆汁淤积。停用这些药物后,生化和组织学异常完全消退。