丁酸盐对半允许细胞中腺病毒感染的影响。

Effect of butyrate on adenovirus infection in semipermissive cells.

作者信息

Iseki S, Baserga R

出版信息

Virology. 1983 Jan 15;124(1):188-91. doi: 10.1016/0042-6822(83)90304-5.

Abstract

Adenovirus 2 stimulated cellular DNA synthesis in quiescent cultures of semipermissive tsAF8 cells and 3T3 cells. Such stimulation was inhibited by Na-butyrate, which also inhibited viral DNA replication in tsAF8 cells. In addition, butyrate inhibited the expression of early regions E1A and E2 of adenovirus 2 in both tsAF8 and 3T3 cells, while it had little effect on permissive HeLa cells.

摘要

腺病毒2在半允许性tsAF8细胞和3T3细胞的静止培养物中刺激细胞DNA合成。这种刺激被丁酸钠抑制，丁酸钠也抑制tsAF8细胞中的病毒DNA复制。此外，丁酸钠在tsAF8和3T3细胞中均抑制腺病毒2早期区域E1A和E2的表达，而对允许性HeLa细胞几乎没有影响。