Andersen A N, Starup J, Tabor A, Jensen H K, Westergaard J G
Acta Endocrinol (Copenh). 1983 Jan;102(1):1-5. doi: 10.1530/acta.0.1020001.
In 15 hyperprolactinaemic, infertile patients achieving 17 bromocriptine-induced pregnancies, the presence or absence of prolactin (Prl) increment in the 3rd trimester of pregnancy was correlated to the basal Prl levels before treatment and after pregnancy. The hyperprolactinaemic patients revealed a marked heterogeneity in the Prl increment compared to normal women. Five patients showed a pronounced increase in serum Prl during gestation, whereas Prl levels were unaltered or decreased slightly in 10 patients. In the latter group of patients serum Prl was significantly (P less than 0.01) lower after pregnancy than before treatment. Our study indicates that some hyperprolactinaemic patients may benefit from a pregnancy, and that these patients probably can be identified, as they do not show any significant changes in Prl levels during pregnancy.
在15例高泌乳素血症的不孕患者中，有17例因服用溴隐亭而怀孕。孕期第三个月泌乳素（Prl）水平是否升高与治疗前及怀孕后的基础Prl水平相关。与正常女性相比，高泌乳素血症患者的Prl升高情况存在显著异质性。5例患者在妊娠期血清Prl显著升高，而10例患者的Prl水平未改变或略有下降。在后一组患者中，怀孕后血清Prl水平显著低于治疗前（P<0.01）。我们的研究表明，一些高泌乳素血症患者可能从怀孕中获益，并且这些患者可能可以被识别出来，因为他们在孕期Prl水平没有任何显著变化。
