Majima S, Watanabe S, Nakao E, Ueda T, Morisawa K, Cho K, Nishioka B, Fujita Y, Takahashi T
Jpn J Surg. 1978 Jun;8(2):111-8. doi: 10.1007/BF02469366.
In order to evaluate the effect of anticancer drugs on the metastatic lesions of the regional lymph nodes from stomach cancers removed after oral administration of 5-FU emulsion, histological examinations of the specimens obtained from 107 surgical cases were carried out. In additional 13 cases with gastric cancer, the active 5-FU concentrations in the regional lymph nodes were determined. The effect of 5-FU emulsion in metastatic lesions as determined was histologically classified into Grades 0 to III according to the severity and extent of damaged cells and cell nests Grades II and III were judged to demonstrate the beneficial effect of the 5-FU emulsion. Such changes were identified in 62.0 per cent of the 242 metastatic lymph nodes, and the effectiveness increased as the total dose of the 5-FU emulsion administered increased (50.9 per cent for 5,000 mg or less, 70.9 per cent for 5,000 to 6,000 mg, and 72.7 per cent for 6,000 mg or more). The rate of effectiveness also varied with the histological type of the primary carcinoma, i.e. the differentiated type being more sensitive. The mean active 5-FU level in the regional lymph nodes was higher after the administration of 5-FU emulsion than of 5-FU solution supporting the earlier animal experiments.
为了评估口服5-氟尿嘧啶乳剂后，抗癌药物对胃癌切除术后区域淋巴结转移灶的影响，对107例手术病例的标本进行了组织学检查。另外，对13例胃癌患者测定了区域淋巴结中活性5-氟尿嘧啶的浓度。根据受损细胞和细胞巢的严重程度和范围，将5-氟尿嘧啶乳剂对转移灶的影响进行组织学分级，分为0至III级，II级和III级被判定为显示5-氟尿嘧啶乳剂的有益效果。在242个转移淋巴结中，62.0%出现了上述变化，并且随着5-氟尿嘧啶乳剂给药总剂量的增加，有效性提高（5000mg及以下为50.9%，5000至6000mg为70.9%，6000mg及以上为72.7%）。有效性发生率也因原发性癌的组织学类型而异，即分化型更敏感。与5-氟尿嘧啶溶液相比，口服5-氟尿嘧啶乳剂后区域淋巴结中的平均活性5-氟尿嘧啶水平更高，这支持了早期的动物实验。
