Luft F C, Rankin L I, Bloch R, Willis L R, Fineberg N S, Weinberger M H
Am J Kidney Dis. 1983 Jan;2(4):464-70. doi: 10.1016/s0272-6386(83)80079-1.
To examine the effects of increasing dietary sodium intake on natriuresis, filtration rate, and renal blood flow following rapid volume expansion, we infused 2-liter normal saline over 2 hr into normal men in balance at 10, 300, 600, and 800 mEq/day sodium intake. Natriuresis and kaliuresis were related to prior sodium intake. Fractional excretion of sodium (6%-7%) was maximal at the 600 mEq/day sodium intake and increased no further at the 800 mEq/day sodium intake. Although blood pressure increased with rapid saline infusion, natriuresis and blood pressure were not associated. Creatinine clearance decreased or remained constant, while PAH clearance decreased during saline infusion at each level. The data suggest that although natriuresis following rapid saline infusion is dependent upon prior sodium intake, under given circumstances it may be independent of glomerular filtration rate, renal blood flow, or blood pressure.
为了研究快速扩容后增加膳食钠摄入量对尿钠排泄、滤过率和肾血流量的影响，我们在钠摄入量分别为10、300、600和800 mEq/天的情况下，对处于钠平衡状态的正常男性在2小时内输注2升生理盐水。尿钠排泄和尿钾排泄与先前的钠摄入量有关。钠排泄分数（6%-7%）在钠摄入量为600 mEq/天时最高，在800 mEq/天时不再进一步增加。尽管快速输注生理盐水后血压升高，但尿钠排泄与血压无关。肌酐清除率降低或保持不变，而在每个水平输注生理盐水期间，对氨基马尿酸清除率降低。数据表明，尽管快速输注生理盐水后的尿钠排泄取决于先前的钠摄入量，但在特定情况下，它可能与肾小球滤过率、肾血流量或血压无关。
