Parker C R, Cutrer S, Casey M L, MacDonald P C
Am J Obstet Gynecol. 1983 Feb 15;145(4):427-32. doi: 10.1016/0002-9378(83)90312-5.
The present investigation was conducted to evaluate the potential for the transfer of deoxycorticosterone (DOC) and deoxycorticosterone sulfate (DOC-SO4) from the fetal to the maternal compartment in near-term human pregnancy. To do so we measured progesterone, DOC, and DOC-SO4 in maternal venous serum and in umbilical arterial and venous sera. The levels of DOC and DOC-SO4 in maternal serum were significantly correlated to each other and to those of progesterone in maternal serum. However, there was no correlation between the levels of DOC or DOC-SO4 in umbilical arterial or venous sera and those of these steroids in maternal serum. Although there was no difference in the concentrations of DOC in umbilical arterial or venous serum, there was a highly significant difference in the umbilical arterial and venous concentrations of DOC-SO4. We conclude that the potential exists for DOC-SO4 from umbilical arterial plasma to enter trophoblasts where it could be hydrolyzed to DOC. The DOC so formed could then be redistributed primarily to the maternal but also to the fetal compartment.
本研究旨在评估在接近足月的人类妊娠中，脱氧皮质酮（DOC）和硫酸脱氧皮质酮（DOC-SO4）从胎儿向母体转运的可能性。为此，我们检测了母体静脉血清以及脐动脉和脐静脉血清中的孕酮、DOC和DOC-SO4。母体血清中DOC和DOC-SO4的水平彼此之间以及与母体血清中的孕酮水平均显著相关。然而，脐动脉或脐静脉血清中DOC或DOC-SO4的水平与母体血清中这些类固醇的水平之间并无相关性。尽管脐动脉或脐静脉血清中DOC的浓度没有差异，但脐动脉和脐静脉中DOC-SO4的浓度存在高度显著差异。我们得出结论，脐动脉血浆中的DOC-SO4有可能进入滋养层细胞，并在其中水解为DOC。如此形成的DOC随后可能主要重新分布到母体，但也会分布到胎儿体内。
