男性和女性体内脱氧皮质酮及硫酸脱氧皮质酮的代谢
Metabolism of deoxycorticosterone and deoxycorticosterone sulfate in men and women.
作者信息
Casey M L, MacDonald P C
出版信息
J Clin Invest. 1982 Aug;70(2):312-9. doi: 10.1172/jci110619.
Abstract
In this investigation we found that little of intravenously infused [14C]deoxycorticosterone (DOC) was converted to [14C]DOC-SO4 that entered plasma. Moreover little of intravenously infused [3H]DOC-SO4 was metabolized by way of DOC except by intestinal bacterial enzymes. However evidence was obtained that plasma DOC is converted to DOC-SO4 in liver, but little of the DOC-SO4 formed in liver escapes into blood; rather the DOC-SO4 enters bile and in the intestine is converted, in part, to progesterone (or metabolites thereof) by the action of bacterial enzymes. The estimated intrahepatic fractional conversion of DOC to DOC-SO4 was significantly greater in premenopausal women (0.72 +/- 0.118, mean +/- SEM) than in men (0.28 +/- 0.036, P less than 0.005).
摘要
在本研究中，我们发现静脉注射的[14C]脱氧皮质酮（DOC）很少转化为进入血浆的[14C]DOC-SO4。此外，静脉注射的[3H]DOC-SO4除了被肠道细菌酶代谢外，很少通过DOC途径代谢。然而，有证据表明血浆中的DOC在肝脏中转化为DOC-SO4，但肝脏中形成的DOC-SO4很少逸入血液；相反，DOC-SO4进入胆汁，并在肠道中通过细菌酶的作用部分转化为孕酮（或其代谢产物）。绝经前女性肝脏中DOC向DOC-SO4的估计分数转化率（0.72±0.118，平均值±标准误）显著高于男性（0.28±0.036，P<0.005）。
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引用本文的文献
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Origin of urinary nonconjugated 19-nor-deoxycorticosterone and metabolism of infused radiolabeled 19-nor-deoxycorticosterone in men and women.男性和女性尿液中非结合型19-去甲-脱氧皮质酮的来源及注入放射性标记的19-去甲-脱氧皮质酮的代谢情况。
J Clin Invest. 1985 Apr;75(4):1335-8. doi: 10.1172/JCI111834.
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