体内肝脏Fc受体功能的证明。
Demonstration of hepatic Fc receptor function in vivo.
作者信息
Yousaf N, Howard J C, Williams B D
机构信息
Department of Rheumatology, University Hospital of Wales, Cardiff.
出版信息
Clin Exp Immunol. 1989 Nov;78(2):278-84.
We describe an investigation of the Fc-receptor dependent function of the hepatic component of the mononuclear phagocyte system (MPS) in rats. Erythrocytes sensitized with the rat IgG2b monoclonal antibody (JY1/98) were cleared by the liver in decomplemented splenectomized rats. This immune clearance was Fc-receptor dependent since it was effectively inhibited by immune complexes of bovine serum albumin (BSA) and rabbit-anti-BSA antibody formed either in vivo or in vitro. Immune complexes formed with F (ab')2 fragment of the rabbit anti-BSA antibody had no effect. Heat-aggregated human gamma globulin was virtually without any competitive activity in the Fc-mediated clearance system. Immune complexes inhibited the hepatic clearance of antibody-sensitized erythrocytes but did not have a significant effect on the early rapid removal of erythrocytes pre-coated with antibody and complement.
我们描述了一项对大鼠单核吞噬细胞系统（MPS）肝脏组分的Fc受体依赖性功能的研究。用大鼠IgG2b单克隆抗体（JY1/98）致敏的红细胞在补体缺失的脾切除大鼠中被肝脏清除。这种免疫清除是Fc受体依赖性的，因为它被体内或体外形成的牛血清白蛋白（BSA）与兔抗BSA抗体的免疫复合物有效抑制。用兔抗BSA抗体的F（ab'）2片段形成的免疫复合物没有作用。热聚集的人γ球蛋白在Fc介导的清除系统中几乎没有任何竞争活性。免疫复合物抑制了抗体致敏红细胞的肝脏清除，但对预先包被抗体和补体的红细胞的早期快速清除没有显著影响。
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