患有房室缺损的父母的后代出现先天性心脏病的证据。
Evidence of congenital heart disease in the offspring of parents with atrioventricular defects.
作者信息
Emanuel R, Somerville J, Inns A, Withers R
出版信息
Br Heart J. 1983 Feb;49(2):144-7. doi: 10.1136/hrt.49.2.144.
Abstract
Fifty-two of the 56 offspring from 90 patients with proven atrioventricular defects were examined. There were five with congenital heart disease. The defects were concordant in three and discordant in two. The mother was the affected propositus in all cases. In this relatively small sample the incidence of congenital heart disease in the offspring of parents with atrioventricular defects was 9.6%, or 14.3% if only the female propositi were considered. This is a much higher figure than that reported for the simple forms of isolated congenital heart disease.
摘要
对90例确诊为房室缺损患者的56名后代中的52名进行了检查。其中有5例患有先天性心脏病。3例缺损一致，2例不一致。所有病例中母亲均为患病先证者。在这个相对较小的样本中，房室缺损父母的后代中先天性心脏病的发病率为9.6%，如果仅考虑女性先证者，则为14.3%。这一数字远高于报道的单纯形式的孤立性先天性心脏病的发病率。
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