Osipov S G, Turlubekov K K, Titov V N, Rudnev V I, Shkhvatsabaia I K
Biull Eksp Biol Med. 1983 Feb;95(2):21-3.
The authors studied the pattern of changes in human platelet aggregation (PA) during platelet interaction with soluble immune complexes. Addition of antisera to human IgG and IgM to platelet plasma led to ADP-induced PA suppression. Analogous suppression of human PA was detected upon exposure to xenogenous immune complexes formed during incubation of guinea-pig blood serum with rabbit serum against guinea-pig gamma-globulin. PA was suppressed to a lesser degree upon antigen excess and was suppressed negligibly upon antibody excess. Activation and inactivation of complement did not affect the degree of PA suppression with immune complexes. Suppression of human PA with immune complexes attests to the existence of a previously unknown phenomenon apparently caused by platelet blockade by soluble immune complexes.
作者研究了人类血小板与可溶性免疫复合物相互作用过程中血小板聚集（PA）的变化模式。向血小板悬液中添加抗人IgG和IgM抗血清会导致ADP诱导的PA抑制。当暴露于豚鼠血清与兔抗豚鼠γ-球蛋白血清孵育过程中形成的外源性免疫复合物时，也检测到了类似的人类PA抑制现象。在抗原过量时，PA的抑制程度较小，而在抗体过量时，PA的抑制作用可忽略不计。补体的激活和失活并不影响免疫复合物对PA的抑制程度。免疫复合物对人类PA的抑制证明了一种此前未知现象的存在，这种现象显然是由可溶性免疫复合物对血小板的阻滞引起的。
