可溶性抗原-抗体复合物诱导的多形核白细胞趋化作用。
Chemotaxis for polymorphonuclear leucocytes induced by soluble antigen- antibody complexes.
作者信息
Leung-Tack J, Maillard J, Voisin G A
出版信息
Immunology. 1977 Dec;33(6):937-45.
Guinea-pig soluble immune complexes formed either by simply mixing antibody and antigen in excess or by redissolving a washed immune precipitate with antigen, after incubation with fresh serum, could induce a migration of polymorphonuclear leucocytes in vitro. This chemotactic effect of soluble complexes, although less than that of insoluble complexes, persisted despite experimental changes in the specificity, the dose and the class of antibodies. Soluble complexes of various molecular compositions induced chemotaxis but the most efficient complex was of Ab 1 Ag 1 formula. Unlike larger complexes, the Ab 1 Ag 1 complexes induced little or no complement fixation. Another source of chemotactic mediators was needed, apparently related to the esterases of the contact system of coagulation.
豚鼠可溶性免疫复合物，无论是通过简单混合过量的抗体和抗原形成，还是通过将洗涤后的免疫沉淀物与抗原重新溶解（在与新鲜血清孵育后），都能在体外诱导多形核白细胞迁移。可溶性复合物的这种趋化作用，尽管不如不溶性复合物的趋化作用强，但在抗体的特异性、剂量和类别发生实验性变化时仍持续存在。各种分子组成的可溶性复合物都能诱导趋化作用，但最有效的复合物是Ab 1 Ag 1形式。与较大的复合物不同，Ab 1 Ag 1复合物几乎不诱导补体固定或完全不诱导补体固定。显然需要另一种趋化介质来源，这与凝血接触系统的酯酶有关。
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