van der Kogel A J, Sissingh H A
Br J Radiol. 1983 Feb;56(662):121-5. doi: 10.1259/0007-1285-56-662-121.
The effect of misonidazole on the induction of early and late delayed radiation damage in the rat cervical spinal cord has been determined for single doses, daily, and multiple fractions per day of X rays. Paralysis occurred in two separate waves, which could be attributed to histologically different types of damage. Administration of misonidazole before irradiation did not modify the early and late delayed radiation response of the spinal cord. This suggested that the targets for misonidazole and radiation toxicity in the central nervous system are different. Comparison of different types of anaesthesia, Nembutal and Ethrane, with or without breathing oxygen, indicated that hypoxia was not induced in the spinal cord by the experimental conditions. Irradiation with two or three fractions a day showed a reduction in spinal cord tolerance, but this reduction became less with decreasing doses per fraction.
已确定了米索硝唑对大鼠颈段脊髓单次、每日及每天多次X线照射所致早期和晚期延迟性辐射损伤的影响。瘫痪以两个不同阶段出现，这可归因于组织学上不同类型的损伤。照射前给予米索硝唑并未改变脊髓的早期和晚期延迟性辐射反应。这表明米索硝唑和辐射在中枢神经系统中的毒性靶点不同。对不同类型麻醉（戊巴比妥和恩氟烷）在有或无吸氧情况下的比较表明，实验条件未在脊髓中诱发缺氧。每天照射两或三个分次显示脊髓耐受性降低，但随着每次分次剂量的减少，这种降低变得不那么明显。
