老年斑核心蛋白的分离及氨基酸组成
The isolation and amino acid composition of senile plaque core protein.
作者信息
Allsop D, Landon M, Kidd M
出版信息
Brain Res. 1983 Jan 24;259(2):348-52. doi: 10.1016/0006-8993(83)91273-8.
PMID:6824945
Abstract
A new method has been developed for the isolation of intact senile (neuritic) plaque cores from post-mortem brains of patients with Alzheimer's disease. The plaque cores were found to be insoluble in various protein denaturants. The amino acid composition of the plaque core protein does not resemble that of any known form of amyloid.
摘要
已开发出一种新方法，用于从阿尔茨海默病患者的死后大脑中分离完整的老年（神经炎性）斑块核心。发现斑块核心不溶于各种蛋白质变性剂。斑块核心蛋白的氨基酸组成与任何已知形式的淀粉样蛋白均不相似。
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