Ejeckam G C, Idikio H A, Nayak V, Gardiner J P
Can J Surg. 1983 Mar;26(2):170-3.
A 61-year-old man had malignant transformation of an anal condyloma acuminatum, demonstrated by light and electron microscopic studies. Intranuclear virus-like particles were seen in the benign condylomatous koilocytotic cells but these were absent in the malignant cells. Multinucleation, syncytial giant cells and nuclear atypia in a condyloma acuminatum are considered features of in-situ carcinomatous change. Anal condyloma acuminatum requires wide excision and thorough examination of anorectal canal in order to exclude hidden disease, which will predispose to recurrence. Homosexuality is considered a predisposing factor. The authors stress the importance of histopathologic examination of all anorectal warts to exclude malignant change.
一名61岁男性的肛门尖锐湿疣发生了恶性转化，这通过光镜和电镜研究得以证实。在良性湿疣样空泡化细胞中可见核内病毒样颗粒，但在恶性细胞中则不存在。尖锐湿疣中的多核化、合体巨细胞和核异型性被认为是原位癌变化的特征。肛门尖锐湿疣需要广泛切除并对肛管进行彻底检查，以排除隐匿性疾病，因为这会导致复发。同性恋被认为是一个诱发因素。作者强调对所有肛门直肠疣进行组织病理学检查以排除恶性变化的重要性。
