Bishara B, Eitan A, Barzilai A
Dept. of Surgery A, Rambam Medical Center, Haifa.
Harefuah. 1991 Oct;121(7-8):230-1.
A case of squamous cell carcinoma developing in a perianal condyloma acuminatum in a 38-year-old man treated for over 5 years with podophyllin is presented. Although there are many reports of malignant transformation of condyloma acuminatum in the skin and mucosal surfaces of the male and female genitalia, it is quite rare in the perianal region. In this case there were foci of carcinoma in-situ and of frank invasion, as well as areas of squamous cell carcinoma in the large perianal condyloma. The lesion was widely excised, and completely removed, and the site covered with a split-thickness graft from the thigh. Later, repeated dilatations of the anus were required. Repeated histologic examinations of condyloma acuminatum are needed to diagnose possible malignant transformation.
本文报告1例38岁男性，其肛周尖锐湿疣经鬼臼树脂治疗5年多后发生鳞状细胞癌。虽然有许多关于男女生殖器皮肤和黏膜表面尖锐湿疣恶变的报道，但在肛周区域却相当罕见。该病例中，在大的肛周尖锐湿疣内存在原位癌灶、浸润癌灶以及鳞状细胞癌区域。病变被广泛切除并完全清除，然后用大腿的中厚皮片覆盖该部位。后来，需要反复进行肛门扩张。为诊断可能的恶变，需要对尖锐湿疣进行反复组织学检查。
