Fraser C G, Williams P
Clin Chem. 1983 Mar;29(3):508-10.
Analytical, intra-individual, and inter-individual components of variation were estimated from duplicate analyses of 11 plasma analytes in an average of 13 specimens obtained, over a two-day period, from nine patients with impaired renal function. Analytical variance was 17.3% of the total variance for sodium; less than 5% of the total variance for potassium, chloride, bicarbonate, albumin, and calcium; and less than 1% for urea, creatinine, glucose, creatine kinase (EC 2.7.3.2), and alanine aminotransferase (EC 2.6.1.2). Average intra-individual variances were of the same order as those found in healthy individuals. All analytes except glucose showed strong individuality. We postulate that, in nonacute pathological processes where new homeostatic steady states are reached, biological variations around the new set points are of the same order as those found in healthy individuals.
在两天时间内，从9名肾功能受损患者身上平均采集了13份样本，对11种血浆分析物进行了重复分析，估算了分析变异、个体内变异和个体间变异的组成部分。钠的分析变异占总变异的17.3%；钾、氯、碳酸氢盐、白蛋白和钙的分析变异占总变异的比例不到5%；尿素、肌酐、葡萄糖、肌酸激酶（EC 2.7.3.2）和丙氨酸转氨酶（EC 2.6.1.2）的分析变异占总变异的比例不到1%。平均个体内变异与健康个体的变异程度相当。除葡萄糖外，所有分析物均表现出强烈的个体差异。我们推测，在达到新的稳态的非急性病理过程中，围绕新设定点的生物学变异与健康个体的变异程度相当。
