肝硬化患者尿液中异常的三羟基化胆汁酸。
Unusual trihydroxylated bile acids in urine of patients with liver cirrhosis.
作者信息
Amuro Y, Hayashi E, Endo T, Higashino K, Kishimoto S
出版信息
Clin Chim Acta. 1983 Jan 7;127(1):61-7. doi: 10.1016/0009-8981(83)90075-x.
Urine from 20 male patients with liver cirrhosis was analyzed for bile acid constituents by gas chromatography and gas chromatography-mass spectrometry. Five unusual trihydroxy bile acids were found in the urine: norcholic acid in 18; 3 alpha, 7 beta, 12 alpha-trihydroxy-5 beta-cholanoic acid in 9; hyocholic acid in 11; 1 beta, 3 alpha, 12 alpha-trihydroxy-5 beta-cholanoic acid in 12; and allocholic acid in 13 patients. The presence of unusual trihydroxy bile acids was unrelated to the clinical severity of cirrhosis. Norcholic acid was the major trihydroxy bile acid which was found in the urine.
采用气相色谱法和气相色谱-质谱联用法对20例男性肝硬化患者的尿液进行胆汁酸成分分析。在尿液中发现了5种不寻常的三羟基胆汁酸：18例患者中有降胆酸；9例患者中有3α，7β，12α-三羟基-5β-胆烷酸；11例患者中有猪胆酸；12例患者中有1β，3α，12α-三羟基-5β-胆烷酸；13例患者中有别胆酸。不寻常的三羟基胆汁酸的存在与肝硬化的临床严重程度无关。降胆酸是尿液中发现的主要三羟基胆汁酸。
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