Yen C T, Blum P S, Spath J A
Exp Neurol. 1983 Mar;79(3):666-79. doi: 10.1016/0014-4886(83)90031-6.
An investigation was made of the effect on cardiovascular function of electrical stimulation within the midline medullary region of the anesthetized cat. Stimuli consisted of low-intensity trains of pulses. Stimulation sites were defined histologically and in some experiments, detailed stimulus maps were obtained for the effect of electrical stimulation on mean arterial blood pressure (MABP). In other experiments, measurements were made of changes produced by electrical stimulation on heart rate, cardiac output, cardiac contractility, and total peripheral resistance. Comparisons were made between the effect of stimulation at sites on the midline and sites to 1.5 mm more lateral. At midline sites, electrical stimulation most often produced a depression of the MABP. Effective depressor sites were located preferentially in two regions along the anteroposterior axis of the brain stem. At more lateral sites, electrical stimulation elevated the MABP. At most sites, changes in MABP occurred concomitantly with changes in total peripheral resistance while cardiac output was unchanged. Sites where electrical stimulation directly altered heart rate and cardiac contractility had a different distribution within the medulla compared with sites where stimulation changed the MABP.
对麻醉猫延髓中线区域内电刺激对心血管功能的影响进行了研究。刺激由低强度脉冲串组成。刺激部位通过组织学方法确定，在一些实验中，还获得了电刺激对平均动脉血压（MABP）影响的详细刺激图谱。在其他实验中，测量了电刺激对心率、心输出量、心脏收缩力和总外周阻力产生的变化。对中线部位和更外侧1.5毫米处的刺激效果进行了比较。在中线部位，电刺激最常导致MABP降低。有效的降压部位优先位于沿脑干前后轴的两个区域。在更外侧的部位，电刺激使MABP升高。在大多数部位，MABP的变化与总外周阻力的变化同时发生，而心输出量不变。与刺激改变MABP的部位相比，电刺激直接改变心率和心脏收缩力的部位在延髓内的分布不同。
