用于定位砹-211标记药物的α粒子径迹放射自显影术
alpha-Particle track autoradiography for localization of a 211At-astatinated drug.
作者信息
Mitchell J S, Brown I, Carpenter R N
出版信息
Experientia. 1983 Mar 15;39(3):337-9. doi: 10.1007/BF01955337.
PMID:6825808
Abstract
A potential endoradiotherapeutic drug, 6-211At-astato-2-methyl-1,4-naphthoquinol bis (diphosphate salt), incorporating the alpha-emitting radio-halogen astatine-211 of half-life 7.2 h, is shown to be valuable for localization studies by means of alpha-particle track autoradiography in malignant and normal cells and tissues in the mouse with transplanted adenocarcinoma of the rectum.
摘要
一种潜在的内放射治疗药物，6-211At-砹-2-甲基-1,4-萘醌双（二磷酸盐），含有半衰期为7.2小时的发射α粒子的放射性卤素砹-211，通过α粒子径迹放射自显影术在患有直肠移植腺癌的小鼠的恶性和正常细胞及组织中进行定位研究，结果表明该药物具有重要价值。
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