Moriya T
Gen Comp Endocrinol. 1983 Jan;49(1):1-7. doi: 10.1016/0016-6480(83)90001-1.
To elucidate the environmental factors and endocrine mechanisms which are responsible for inducing neoteny in the salamander Hynobius retardatus, the effect of temperature on the growth and metamorphosis of this amphibian, as well as the actions of thyroid hormone and prolactin at low temperature, were studied. (1) The metamorphosis of larvae cultivated at 10 degrees was significantly delayed compared with that of larvae cultivated at 22 degrees, but the metamorphosis was eventually completed. At 4 degrees, metamorphosis never occurred, even after 2 years. (2) Exogenously administered thyroid hormone accelerated metamorphosis at 10 degrees or 22 degrees, but was ineffective in larvae kept at 4 degrees, whether administered by injection or immersion. (3) If a higher concentration of thyroid hormone was given by a single injection to larvae cultured at 4 degrees, an appreciable acceleration of metamorphosis was observed after transferring the larvae to 22 degrees. (4) Unlike thyroid hormone, prolactin promoted growth at 4 degrees.
为阐明导致日本林蛙幼态持续的环境因素和内分泌机制，研究了温度对这种两栖动物生长和变态的影响，以及甲状腺激素和催乳素在低温下的作用。（1）与在22℃培养的幼体相比，在10℃培养的幼体变态显著延迟，但最终完成了变态。在4℃时，即使经过2年，变态也从未发生。（2）外源给予甲状腺激素可加速10℃或22℃下的变态，但对保持在4℃的幼体无效，无论通过注射还是浸泡给药。（3）如果对在4℃培养的幼体单次注射较高浓度的甲状腺激素，将幼体转移到22℃后，可观察到变态有明显加速。（4）与甲状腺激素不同，催乳素在4℃促进生长。
