Heney H W, Stiffler D F
Gen Comp Endocrinol. 1983 Jan;49(1):122-7. doi: 10.1016/0016-6480(83)90015-1.
Electrolyte depletion resulting from 14 days in distilled water, which was changed daily, lowered plasma Na concentration from 108 to 92 mM. Aminoglutethimide was administered on each of the final 3 days of the depletion period in doses of 3 mg/animal. This further depressed Na to 75 mM. Both aldosterone (25 micrograms/animal) and corticosterone (200 micrograms/animal) returned plasma Na to 92 mM. Cortisone (200 micrograms/animal) was ineffective. There were no consistent patterns in plasma K. Renal clearance experiments showed that the same dose of aminoglutethimide decreased fractional tubular Na reabsorption and increased fractional tubular K reabsorption. Aldosterone reversed these trends suggesting that this hormone may play a role in controlling renal electrolyte excretion.
