由于全氟化合物的给药导致的心输出量计算错误。
Errors in calculating cardiac output due to administration of perfluorochemicals.
作者信息
Rosen A L, Gould S A, Sehgal L R, Sehgal H L, Moss G S
出版信息
J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan;54(1):318-20. doi: 10.1152/jappl.1983.54.1.318.
Intravenous administration of perfluorochemicals (PFC) will alter the density (rho)B, the gravimetric specific heat (c)B, and the volumetric specific heat (rho c)B of blood. Changes in hematocrit also influence (rho c)B. The calibration constant employed in the determination of cardiac output (CO) by thermal dilution depends inversely on (rho c)B. We estimate the effect of addition of PFC and changes in hematocrit on (rho c)B. Consider blood to be a mixture of red cells, emulsified PFC particles, and plasma. This leads to the equation: (rho c)cB = 0.96 - 0.11Hct - 0.48Fct. Here Hct and Fct are the fractional volume concentrations of red blood cells and PFC, and (rho c)cB is the calculated specific heat based on the actual composition of blood. CO can be corrected for changes in (rho c)B by the equation: (CO)c = (rho c)sB/(rho c)cBo. Here (CO)o is the observed cardiac output, (rho c)sB is the standard specific heat of blood used in the calculation of (CO)o, and (CO)c is the corrected cardiac output. We have observed laboratory situations where the correction factors have been as high as 10%.
静脉注射全氟化合物（PFC）会改变血液的密度（ρ）B、重量比热（c）B和体积比热（ρc）B。血细胞比容的变化也会影响（ρc）B。通过热稀释法测定心输出量（CO）时使用的校准常数与（ρc）B成反比。我们估计添加PFC和血细胞比容变化对（ρc）B的影响。将血液视为红细胞、乳化的PFC颗粒和血浆的混合物。这就得到了方程：（ρc）cB = 0.96 - 0.11Hct - 0.48Fct。这里Hct和Fct分别是红细胞和PFC的体积分数浓度，（ρc）cB是根据血液实际成分计算出的比热。CO可以通过以下方程校正（ρc）B的变化：（CO）c = [（ρc）sB/（ρc）cB]（CO）o。这里（CO）o是观察到的心输出量，（ρc）sB是计算（CO）o时使用的血液标准比热，（CO）c是校正后的心输出量。我们在实验室中观察到校正因子高达10%的情况。
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