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狂犬病病毒毒力的分子基础。II. 鉴定CVS糖蛋白上与毒力相关的位点。

Molecular basis of rabies virus virulence. II. Identification of a site on the CVS glycoprotein associated with virulence.

作者信息

Coulon P, Rollin P E, Flamand A

出版信息

J Gen Virol. 1983 Mar;64 Pt 3:693-6. doi: 10.1099/0022-1317-64-3-693.

DOI:10.1099/0022-1317-64-3-693
PMID:6827249
Abstract

Nine anti-G monoclonal antibodies were used to select mutants of the CVS strain of rabies virus resistant to neutralization. Seven mutants were avirulent in adult mice and two others exhibited an attenuated pathogenicity. Both categories were resistant to monoclonal antibodies 194-2 and 248-8. Virulence appears to be associated with a particular configuration of a region of the glycoprotein which is located at the intersection of the epitopes recognized by these two monoclonal antibodies. Our results confirm the role played by the glycoprotein in the neurovirulence of rabies virus.

摘要

使用9种抗G单克隆抗体筛选对中和有抗性的狂犬病病毒CVS株突变体。7个突变体在成年小鼠中无毒力，另外2个表现出致病性减弱。这两类突变体均对单克隆抗体194 - 2和248 - 8有抗性。毒力似乎与糖蛋白一个区域的特定构型有关，该区域位于这两种单克隆抗体识别的表位的交叉点处。我们的结果证实了糖蛋白在狂犬病病毒神经毒力中所起的作用。

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